Black federal and provincial legislators concluded a successful three days of meetings today, June 10. The inaugural Black Government Leaders Summit took place at the historic Black Loyalist Heritage Centre in Birchtown, near Shelburne. “The time is right for this first meeting,” said Tony Ince, Minister of Communities, Culture and Heritage. “A record number of federal and provincial leaders are black, the UN Decade for People of African Descent has been declared, and public interest in Black history has been focused by Lawrence Hill’s The Book of Negroes.” “This is a unique opportunity to address issues affecting the black community across the country,” said Michael Coteau, Ontario Minister of Tourism, Culture and Sport. “In the absence of a single hint of partisanship, we were able to carefully focus our discussions on black Canadians, including how to better co-ordinate efforts among black legislators across jurisdictions.” Delegates began with presentations from international and local experts. Gloria Nwabuogu, human rights officer with the United Nations Office of the High Commissioner for Human Rights in Geneva, explained the significance of and strategy behind the International Decade for People of African Descent. Peter Flegel, director of programs and communications for the Michaëlle Jean Foundation, described his organization’s use of arts to engage youth in generating social change. Wayn Hamilton, executive director, African Nova Scotian Affairs, gave insight into Nova Scotia’s unique model to support healthy, thriving black communities. In the afternoon, delegates brought forward concerns to establish the group’s priorities for the future. The leaders adopted United Nations Resolution 69/16, article 9, sections A and B, as the group’s guiding principles. The sections urge working toward the full enjoyment of human rights, full participation in society for people of African descent, and toward better understanding of, and respect for, their culture and contributions to social development. They also agreed to meet twice during the next year to tackle four initial areas of priority: youth engagement, economic opportunities, education and health. The leaders thanked event sponsor TD Canada, for its recognition of the summit’s significance to all Canadians.
New Delhi: A Delhi court on Tuesday granted exemption from personal appearance to Delhi Chief Minister Arvind Kejriwal and three others in a defamation complaint filed by Bharatiya Janata Party (BJP) leader Rajiv Babbar. However, Additional Chief Metroplitan Magistrate Samar Vishal asked Kejriwal, Rajya Sabha member Sushil Kumar Gupta, MLA Manoj Kumar and Aam Aadmi Party (AAP) spokesperson Atishi to appear before the court on June 7, the next date fixed for hearing. Also Read – Odd-Even: CM seeks transport dept’s views on exemption to women, two wheelers, CNG vehiclesOn March 15, the court issued summons to Kejriwal and the others to appear before it on April 30. Advocate Mohd Irshad requested the court to grant exemption to all these political leaders as they are busy in political events in Delhi and Haryana. The court was hearing the defamation case filed by Babbar, who has sought proceedings against Kejriwal and others for harming the reputation of the BJP by blaming the party for the deletion of names of “voters” from the electoral rolls in Delhi. “All the accused made accusations against BJP in a calculated manner with the sole intention to portray a negative image of BJP in relation to the voters belonging to certain sections of society, namely, Bania, Poorvanchalis, Muslims, among others. The reputation of the complainant has been damaged beyond repair,” Babbar said.
Rabat – The Atlas Workshops are offered to young emerging filmmakers in the Middle East and Africa. The primary aims of the workshops is to assist filmmakers who are working on their feature-length narrative or documentary films. It also seeks to create a platform that would allow them to exchange their thoughts and experiences with 150 Moroccan and international professionals.“Eight projects in development and six films in post-production, originating from nine countries, have been invited to take part. They will benefit from a tailor-made day-long consultation with professionals who will provide them artistic feedback, as well the Industry point of view. At the end of the workshop, a jury will award a Development Prize of €10,000 and a post-production prize of €20,000 to the best projects,” according to the website for the festival. Read Also: ‘Morocco: Love in Times of War,’ Spanish Series about the Rif War Premieres on NetflixNetflix is seeking to boost its market share through business cooperation in the Middle East and Africa. The company is building partnerships across the two regions and investing in local original productions. Morocco seems to be the perfect choice for Netflix as it is a gate to both Africa and the Middle East. “I don’t want us to be deprived of any great storytellers and I know there’s going to be some in [Arabic-speaking] countries — we know there are, and we want to access them,” said Todd Yellin, Vice-President of Product Innovation at Netflix.“It’s healthy psychologically…when people are exposed to people of other nations and what they do, then you gain understanding, and we start eroding away all the ignorance. So that’s the goal,” he added.Online video streaming services like Netflix are booming in the Middle East and most of Africa.“Rapid growth in premium online video services across the Middle East and Africa is a sure sign that Internet TV is a truly global phenomenon,” said Tony Gunnarsson, principal analyst with Ovum’s Media.
After praising “major gains” in several areas, including education, food production, election preparations and vaccination programmes, the communiqué by the ad hoc meeting of some 20 ranking ministers expressed “deep concern over the lawlessness that results, in parts of Afghanistan, from arbitrary rule by local factional commanders.”The group, which discussed international support for Afghanistan yesterday with Afghan President Hamid Karzai, also condemned continuing narcotics production and attacks on aid programmes.The communiqué said the ministers “urged all Afghan regional military and political leaders to respect the authority and decrees of the Afghan Transitional Authority.”In addition to President Karzai, the Deputy Prime Ministers of Turkey and Turkmenistan and the Foreign Ministers of the permanent members of the Security Council, China, France, United Kingdom, Russian Federation and United States, attending the Wednesday meeting.Other participants included the Foreign Ministers of Canada, Denmark, Germany, Iran, India, Italy, Netherlands, Norway, Pakistan, Romania, Tajikistan and Uzbekistan, as well as high-ranking delegates from Saudi Arabia, Japan, the European Commission and the Council of the European Commission.
WASHINGTON – U.S. companies stepped up hiring in May, a private survey found, evidence that employers remain confident in the economy even after it contracted at the start of the year.Payroll processor ADP said Wednesday businesses added 201,000 jobs last month, up from just 165,000 in the previous month. April’s increase was the smallest in a year and a half.The figures suggest that the economy is recovering after it shrank at a 0.7 per cent annual rate in the first quarter. On Friday, the government will issue its official jobs report for May. Economists forecast it will show that employers added 227,000 jobs, and the unemployment rate remained 5.4 per cent.The ADP survey covers only private businesses, however, and frequently diverges from the official figures.Construction companies added 27,000 jobs, ADP said, while manufacturers cut 5,000 jobs. The drop in factory jobs likely reflects the impact of the stronger dollar, which makes U.S. goods more expensive overseas and cuts into export sales.Other recent reports have painted a mixed picture of the economy. Consumers remain cautious and are reluctant to spend their savings from lower gas prices, which are about $1 a gallon cheaper than a year ago. On Monday, the government said consumer spending was unchanged in April. Instead, the savings rate rose to 5.6 per cent from 5.2 per cent.Yet Americans were willing to spend more on cars last month. Auto sales rose 2 per cent in May to 1.64 million cars and trucks, according to Autodata Corp. That was the fastest sales pace since July 2005.And a survey of manufacturing firms showed that factory activity grew at a faster pace in May than the previous month, driven higher by more new orders and greater hiring.Overall, analysts expect the economy will expand at about a 2 per cent annual pace in the second quarter. That would leave growth in the first half of the year barely above 0.5 per cent, down from a 3.6 per cent in the second half of last year. In this April 2, 2015, photo, David Dunn from Chickamauga, Ga., right, stands in line with hundreds of other job seekers at The Colonnade in Ringgold, Ga., to attend a huge 15-county job fair. Payroll processor ADP reports how many jobs private employers added in May on Wednesday, June 3, 2015. (Dan Henry/Chattanooga Times Free Press via AP) THE DAILY CITIZEN OUT; NOOGA.COM OUT; CLEVELAND DAILY BANNER OUT; LOCAL INTERNET OUT by Christopher S. Rugaber, The Associated Press Posted Jun 3, 2015 6:48 am MDT Last Updated Jun 3, 2015 at 9:40 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Survey: US business hiring accelerates in May to 201,000, a sign of confidence in economy
“Enforced disappearance is a human rights violation that repeats itself daily for the families of the disappeared,” said Ravina Shamdasani, Spokesperson for the UN Human Rights Office (OHCHR). “We call on authorities in all parts of the world to redouble their efforts to discover the fate of such individuals and to ensure that the rights to justice and reparation are realized.”The grandson of Estela de Carlotto, the president of the Association of Grandmothers of Plaza de Mayo, was reportedly identified through a DNA test.Ms. Carlotto never met her grandson, who was born in 1978 during her daughter’s clandestine detention by the military. The daughter was killed two months after the birth, with the body returned to Ms. Carlotto. The father was illegally detained by the Government and also killed.The grandson is one of an estimated 500 children who disappeared during Argentina’s 1976-1983 military dictatorship. Only 114 children have been located. “The courage, perseverance and determination that the grandmothers of missing children in Argentina have shown in the last three decades continue to inspire human rights defenders around the world,” Ms. Shamdasani said in reference to the Association of Grandmothers of Plaza de Mayo. Ms. Carlotto founded that non-governmental organization in 1977. It aims to ensure that violations of children’s rights such as those that occurred during the military dictatorship never happen again by demanding the prosecution of all those responsible for the tragedy.In 2010, the UN Educational, Scientific and Cultural Organization (UNESCO) awarded the Grandmothers its Félix Houphouët-Boigny Peace Prize for their “tireless battle for human rights and peace by standing up to oppression, injustice and impunity.”In today’s press briefing, the OHCHR spokesperson stressed that the Grandmothers and other associations in the region have made great contribution to the human rights system, and have advanced the application of scientific methods towards resolution of human rights issues.
A sell-out crowd attended Cuvée 2015 to celebrate Ontario’s grape and wine industry. The accounting is finished, and organizers of Cuvée 2015 report that this year’s grape and wine celebration event generated net revenues of $33,000, most of which will go to supporting student scholarships and grape and wine research.This was the first year that Cuvée was organized by Brock University’s Cool Climate Oenology and Viticulture Institute, a sold-out evening that took place Feb. 27 at the Fallsview Casino.Of the net proceeds, $5,000 will go to support the Niagara Community Foundation, in recognition of that organization’s work in overseeing Cuvée for several years before CCOVI assumed responsibility.Of the remaining $28,000 in net proceeds, $15,000 will be used to establish scholarships and $13,000 will go toward industry driven research that supports the grape and wine industry.Organizers intend to use the $15,000 scholarship money as follows:scholarships of $5,000 and $2,500 respectively for students in the Oenology and Viticulture bachelor of science program at Brocka $2,500 scholarship for a student pursuing a Certificate in Grape and Wine Technologyand a $5,000 scholarship to establish a Cuvée award for a graduate student in Oenology and Viticulture.CCOVI Director Debbie Inglis said the proceeds are a tribute to the staff, volunteers and organizing committee members who made the event a success.“Staging an event like Cuvée involves hundreds of hours of work and a lot of commitment,” said Inglis. “But it’s worth it when you see the profits going to help students complete their education.”Cuvée 2015 drew positive reviews from many in attendance. Faces in the crowd this year ranged from Ontario’s Lieutenant Governor to senior community, political and industry figures.Niagara Regional Chair Alan Caslin saluted “the dedication of Brock staff and volunteers who made this year’s Cuvée an outstanding community event in support of Niagara’s post-secondary students and our renowned wine industry.”“I had a great time and look forward to next year,” said Caslin.John Fisher, President and CEO of Walker Industries, remarked on the successful transition of this year’s event to the new organizing team.“Brock has done an excellent job of carrying on the work of the Niagara Community Foundation in making Cuvée a first class entertainment experience for the people of Niagara,” said Walker.Details on Cuvée 2016 will be announced in the coming weeks.
Although Ohio State’s men’s soccer team hasn’t had the winning season they originally hoped for, two of their last three games are at home, leaving the team with some confidence. Their next challenge will be taking on Akron at home Tuesday. “We feel confident. We had a great week of practice this past week, everybody’s buzzing and very energetic, ” said senior forward Chris Hegngi. “We’re going to give it our best shot and I think we’re going to come away with a great result.” With five of their six wins this season coming at home, the Buckeyes have reason to feel positive about another home victory. Although the Buckeyes fell to the Zips last September, 3-1, coach John Bluem feels that a short turnaround from Friday’s victory against Wright State will be beneficial. “First we’re going to rest, to try to get our legs back under us,” Bluem said. “Then we’ll try to prepare for Akron. They’re a very good team, they’re nationally ranked, they have very good players and a very good speed of play.” Riding an eight game win-streak coming in to Columbus, the No. 3 Zips only have one loss this season. But junior captain Sage Gardner doesn’t see need for concern as long as the Buckeyes connect. “We have to work hard to communicate and stay together defensively,” the defender said. Gardner said OSU’s 2-1 win against Wright State at home on Friday might prepare them when Akron comes to town. “(That) was a good stepping stone into the Akron game because they’ll probably have a majority of possession,” he said. With Akron’s coach Caleb Porter having the highest winning percentage in Division 1 soccer, Bluem knows a strong effort by his players is needed to defeat the Zips. “We’re going to have to be at our very best,” Bluem said. “We’re going to have to be very good defensively to keep ourselves in the game.” Gardner said that as long as the team is at their best, they can secure another win. Nor is he the only one who thinks that as his teammate Hegngi agreed. “We just need to have guys in the right spots,” Hegngi said. “Just make sure we’re strong defensively, but still play our game and try to attack.”
First Lady, Mrs. Sandra Granger joined the Luminous Women’s Group, today, as they began the first leg of their school’s outreach programme, named after the International Women’s Day theme, #BeBoldForChangeGuyana at the St. Joseph High School, in Woolford Avenue.First Lady, Mrs. Sandra Granger poses with the contestants of Miss St. Joseph High School pageant.The First Lady spoke at the event and encouraged the students to be confident and to choose their friend’s wisely. “I know success does not mean being popular or being part of the crowd… You must choose your friends wisely. A friend is not someone you meet on Facebook or someone who encourages you to do harmful things or sets out to embarrass you. A friend is someone who has your back and who you can rely on… I want to hope that you will make lifelong friends during your high schools years… Be bold, choose your own path. Be bold for change Guyana,” Mrs. Granger said. The women of the organisation all spoke on the challenges they faced as young women and encouraged the students to make wise decisions that will benefit them in the long run. In an invited comment Mrs. Ingrid Fung, veteran educator and member of the Luminous Women’s group said that the group has decided to speak with students at schools across Georgetown on issues that are affecting them. “We’re worried about the negative trends coming out of schools and we plan as Luminous women to visit those schools in an effort to educate our young girls and boys,” Mrs. Fung said. (MOTP) Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedFirst Lady praises Bishops’ High School’s successFebruary 19, 2016In “Local News”First Lady to focus on senior citizens, helping agencies to fight TIP, rapeMay 21, 2015In “Politics”Youth Development Initiative rolled out at Lusignan Primary SchoolOctober 4, 2016In “latest news”
Diversified Australian engineering and infrastructure company RCR Tomlinson Ltd has been awarded a contract by MMG Ltd for the construction of a processing plant at MMG’s Dugald River project which is subject to MMG finalising financing arrangements on the project. The contract is valued at approximately A$73 million and work will commence immediately and is scheduled for completion in October 2017.RCR’s scope of work includes project management, fabrication and supply of various structural steel, mechanical and E&I components, construction (SMP and E&I) and commissioning support for a zinc and lead concentrator and associated plant, at the project near Cloncurry in Queensland.MMG is responsible for the plant design and the supply of the key processing equipment. In April MMG welcomed the Queensland Government’s decision to grant the Dugald River zinc project the status of prescribed project. The decision is expected to significantly streamline administrative decisions and accelerate the development of the mine.MMG Chief Executive Officer Andrew Michelmore said the company appreciates the strong support it has received from the Queensland Government. “This decision will support MMG to deliver one of the world’s highest-grade zinc deposits at a time of tightening global zinc supply,” he said. He added that the project, which is still subject to financing, will contribute directly to the North West Queensland Mineral Province at a time when new investment is needed.“The development of Dugald River is expected to provide significant employment, economic and revenue benefits to Cloncurry and Queensland over an expected mine life of more than 30 years. MMG has a proud history in Queensland through the operation of the Century mine and we look forward to working with the state and local governments to make this project a success.”While the project is subject to final financing arrangements, MMG continues to advance with pre-production mine development and anticipates first zinc production in 2018.Based on one of the world’s highest-grade known zinc deposits, Dugald River is a development project in northwest Queensland, Australia. MMG announced an updated development plan for Dugald River in 2015. The plan includes a mine production rate of 1.5 Mt/y and construction of a mill and concentrator able to produce approximately 160,000 t/y of zinc in zinc concentrate over an estimated 28 year mine life. This is expected to place Dugald River within one of the top ten zinc mines globally when operational. Under the updated plan, construction of remaining surface infrastructure facilities will commence in 2016 with first production from a Dugald River concentrator expected during the first half 2018. RCR’s Managing Director & CEO, Dr Paul Dalgleish: “The project for MMG builds on our position as a leader in the construction of major minerals processing plants. We are looking forward to working together with MMG and the local community to successfully deliver these construction works.”
After 4 years on the bench of Hungarian Gyori Audi ETO, Csaba Konkoly is sacked by the team Management. Reason for this kind of decision is creating the conditions of team’s victory in the national championship, the Hungarian Cup and the Champions League. The experience of previous matches shows that achieving this goals has a greater chance with a different type of professional management – is wrote in the official statement.Konkoly was in the club since 2007. With him, Gyori played once in EHF CL Final (2009) and three times (2008,2010,2011) in the semifinals. With current roster, Gorbitz, Lekic, Lunde, Loke and other TOP quality players, Gyori is the favorite No.1 for the EHF Champions League title. ← Previous Story Serbian youngstar Jelena Zivkovic changing NT – Montenegro or Hungary? Next Story → Branko Tamse stays on the Gorenje’s bench Csaba Konkoly
CREWS FROM DUBLIN Fire Brigade were attacked last night as they attended a call out in North Dublin.The fire crew from Kilbarrack Fire Station were called out to Belcamp Cresent in Coolock, but upon arriving their engine was attacked by youths in the area.AttackedThe crew had bricks, bottles and kegs thrown at them. The fire engine was significantly damaged in the incident, with the front windscreen being broken.Gardaí attended the scene and it is believed that none of the crew were injured.It is believed that the Kilbarrack fire station itself also had objects thrown at it last night.FinglasThis was not an isolated attack, as it is believed that a fire crew also had objects thrown at them in the Finglas area, resulting in the gardaí public order unit being called to the scene.Photo shows gardaí public order unit in protective gear at the scene in Finglas last night.Attacks on the fire brigade were not isolated to the capital city. Last night there were reports that a fire engine in Waterford was also set upon.Halloween nightHalloween night is one of the busiest nights of the year for the fire brigade. The capital’s fire service responded to more than 600 call-outs this Halloween night.National Chairman of the Irish Fire and Emergency Services Association yesterday appealed to the public throughout the country to allow firefighters and other emergency personnel to be allowed to do their work over Halloween “without injury and assault or damage to emergency vehicles,” he said.Read: Stockpiling for Halloween bonfire causes city centre flat blaze>Read: Water restrictions ‘may endanger public safety’ at busy time for fire brigade>
A fast-moving fire destroyed a house, a detached garage and a car, and damaged a second house near Clark College Thursday afternoon. It was one of two nearly concurrent major fires that stretched firefighting resources throughout the metro area.The fire erupted about 4:40 p.m. at 1517 East Reserve St. Witnesses told firefighters they heard popping and saw something flying in the air.The fire quickly spread to a detached garage behind the car, then a house, and then the neighboring house to the north.A Vancouver Fire Department spokesman said a passerby went into the burning house to help the resident and her three dogs escape.It was 104 degrees in Vancouver when the fire started, the hottest Aug. 3 on record, and officials had warned all day the fire conditions in Clark County were extreme.
Hanamkonda: The mentally challenged persons need a helping hand, Child Welfare Committee chairman Mandala Parashuramulu said, speaking at a meeting that focused on ‘Empowerment of mentally challenged – social responsibility’ organised by Mallikamba Manovikasa Kendram here on Monday.”It requires a lot of care and patience when we deal with the mentally challenged. Unless people have wholeheartedness, it’s difficult to look after the welfare of the mentally challenged,” he said. Even though the number of mentally retarded is high in the erstwhile Warangal district, the way the non-governmental organisations (NGOs) are responding to their cause is commendable, Parashuramulu said. Also Read – Karimnagar is Smart City only for namesake: DYFI Advertise With Us Speaking on the occasion, Prof Padma stressed on the need for more awareness programmes to sensitise the parents of mentally challenged. She said the government should assist the NGOs working for the welfare of mentally challenged. She urged the government to ensure exclusive facilities for issuing SADAREM certificates to these challenged persons. Child protection officer S Praveen Kumar said that those NGOs running institutions for the protection of boys and girls must possess licences as per juvenile act. Child Line coordinator Ragi Krishnamurthy, B Ramaleela and Spandana, NGO, organiser Sucharitha Reddy were among others present.
Beijing : At least 18 people were killed and one million others evacuated from their homes as typhoon Lekima, the ninth one to hit China this year, slammed into the east coast of the country on Saturday, causing extensive damage and disrupting transport. According to Xinhua news agency, the death toll rose to 18 as five more bodies were found on Saturday following a typhoon-triggered barrier lake burst in China’s Zhejiang province. Also Read – Watch: Donald Trump says Florida faces absolute monster hurricane Advertise With Us At least 14 people were missing, said the agency. Over 200 buildings were destroyed and another 3,200 damaged, according to state broadcaster China Central Television. The monster storm made landfall in the early hours in Wenling, a city in China’s Zhejiang province, packing winds of 187 km per hour and was expected to head up towards Shanghai, Xinhua news agency reported. Also Read – Pakistan test-fires 290-km range missile Advertise With Us Yongjia County in Zhejiang province was the worst hit. The typhoon brought heavy rainstorms in the area and caused a landslide that blocked the rivers, raising the water level to a maximum of 10 metre within 10 minutes and trapping 120 villagers. More than 700,000 people in the province were evacuated, 110,000 of whom were housed in shelters, while another 2,53,000 were moved to other safe areas in Shanghai. Advertise With Us The province shut down hundreds of ferries, along with flights and suspended sections of its railway lines. The super typhoon also knocked out power and downed thousands of trees. Over 4,000 flights had been cancelled since Friday. Lekima also forced Shanghai to suspend services on several of its metro lines, according to the local government’s official WeChat account. Taiwanese airlines cancelled about 520 international and domestic flights, South China Morning Post reported citing local aviation authorities.
By Lauren Poteat, Special to the AFROLife may have just gotten a little sweeter for small performing arts venues and artists, looking to capitalize on the intimacy, originality and authenticity of their local music.On Oct. 30, legislation B22-577 the “Performing Arts Promotion Amendment Act of 2017,” originally proposed by Councilmember Robert White (D- At Large) last year, was up on the table for discussion.Herbert Scott, Aaron Meyers, Council member Robert White (D- At Large), Graham Smith-White, Alisha Edmonson and Omrao Brown at the D.C. Council hearing advocating for to incentivizing businesses that promote live performances and local artists. (Courtesy Photo/Robert White Twitter)Intended to promote local performing artists by giving incentives to businesses that host live performances, local musicians and small venue owners gathered in the D.C. Council office to solicit amendments.“Community music hubs serve more than just alcohol,” Graham Smith-White, a local performer and sound engineer testified. “It’s a place to gather, to try new forms of art, music and culture.”“We’ve lost a lot of spaces to perform at, so it would be good to see within the bill, something that incentivizes growth,” White continued. “Small venues are very important and allows for creative spaces for people to try new disciplines and skills, in an atmosphere that is more free and creative… And with the rising rent and the way the general economy is, it is important to function as a business and make that leap.”Chris Naoum, co-founder of “Listen Local First D.C.” also expressed his concerns for the virtually extinct local music hubs and the current bill.“Small D.C. local venues act as a great hub for live music,” Naoum said. “They act as a way to allow musicians to work their way up to bigger theatres like Howard and Warner.”“So it is a necessity to address some of the issues inside of the current bill including properly paying all artists, not allowing them to work for free, increasing 150 person venue capacity, adjusting the $750,000 gross penalization and re-evaluating the credit cap of $10,000 a year.”Not impartial to the recommendations, Councilmember Jack Evans, who spearheaded the meeting, stated that he “really wanted to focus on these issues” and how to make it better.Highlighting popular small music venues including “Marvin’s,” “Blue’s Alley” and “Twin’s Jazz” all located in northwest, Councilmember White also shared his sentiments on upgrading the bill.“I wrote this bill to address the loss of performing arts venues in the District and to give more businesses an incentive to open their space to our talented residents,” White said. “D.C.’s arts scene is legendary. Our job is to make sure it continues to be.”
More information: CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes, Protein & Cell, April 2015. DOI: 10.1007/s13238-015-0153-5 . http://link.springer.com/article/10.1007%2Fs13238-015-0153-5ABSTRACTGenome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISPR/Cas9 in human pre-implantation embryos. In this report, we used tripronuclear (3PN) zygotes to further investigate CRISPR/Cas9-mediated gene editing in human cells. We found that CRISPR/Cas9 could effectively cleave the endogenous β-globin gene (HBB). However, the efficiency of homologous recombination directed repair (HDR) of HBB was low and the edited embryos were mosaic. Off-target cleavage was also apparent in these 3PN zygotes as revealed by the T7E1 assay and whole-exome sequencing. Furthermore, the endogenous delta-globin gene (HBD), which is homologous to HBB, competed with exogenous donor oligos to act as the repair template, leading to untoward mutations. Our data also indicated that repair of the HBB locus in these embryos occurred preferentially through the non-crossover HDR pathway. Taken together, our work highlights the pressing need to further improve the fidelity and specificity of the CRISPR/Cas9 platform, a prerequisite for any clinical applications of CRSIPR/Cas9-mediated editing.See also: The ISSCR has responded to the publication of gene editing research in human embryosvia Nature It has been only recently that scientists have had a tool that allows for directly editing a genome—called CRISPR, it allows for removing a single (defective) gene from a genome and replacing it with another one, to prevent genetic diseases. CRISPR has been used to edit animal embryos and adult stem cells, but up till now, no one has used the technique to edit the genome of human embryos due to ethical issues—or if they have, they have not acknowledged it publicly—this effort by the team in China has crossed that ethical line and because of that the announcement will likely incite condemnation by some and stir a new round of debate regarding the ethics of conducting such research.The researchers report that their desire was to see how well CRISPR would work on human embryos. To find out, they collected 86 doubly fertilized embryos from a fertilization clinic—such embryos have been fertilized by two sperm and cannot mature beyond just a tiny clump of cells, they die naturally before growing into anything. The team reports that 71 of the embryos survived to grow enough for use in the CRISPR experiment. Unfortunately, the researchers found that the technique worked properly on just a fraction of the total, and only small percentage of those managed to relay the new gene properly when they split. They also found that sometimes the procedure wound up splicing the wrong gene segment, which led to inserting new genes in the wrong places—which in normal embryos could lead to a new disease. Additionally, of those that did get spliced and put in the right place, many were mosaic, a term used to describe a mix of old and new genes, which in addition to also leading to a new disease, could lead doctors to misidentify gene splicing results in normal embryos.The researchers conclude by suggesting that the problems they encountered should be investigated further before any type of clinical application is begun. © 2015 Phys.org CRISPR/Cas-derived technology offers the ability to dive into the genome and make a very precise change. Citation: Chinese team performs gene editing on human embryo (2015, April 23) retrieved 18 August 2019 from https://phys.org/news/2015-04-chinese-team-gene-human-embryo.html (Phys.org)—A team of researchers in China has announced that they have performed gene editing on human embryos. In their paper uploaded to the open access site Protein & Cell (after being rejected by Nature and Science) the researchers defended their research by pointing out that the embryos used in their research were non-viable. Journal information: Nature Explore further Precise gene editing in monkeys paves the way for valuable human disease models , Science This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Global Nerve Repair and Regeneration Market are expected to reach $13,938 million by 2023, growing at a CAGR of 13.0 % during the forecast period, 2019-2023.Get the Sample Report @ https://www.alliedmarketresearch.com/request-sample/299?utm_source=Hitechnews&utm_medium=NiranjanThe complex, delicate structures that make up the nervous system-the brain, spinal cord, and peripheral nerves are susceptible to various types of injury ranging from trauma to neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. Peripheral nerves link your brain and spinal cord to the other parts of your body, such as your muscles and skin.The growth of the global nerve repair and regeneration market is driven by an increase in the incidence of neurological diseases & peripheral nerve injuries in the geriatric population, the launch of innovative products for nerve repair & regeneration, and surge in government expenditure in the healthcare sector and favorable reimbursement policies. Additionally, growth in patient awareness and the emergence of healthcare expenditure in emerging economies would provide lucrative opportunities for emerging marking players in the near future. However, the lack of skilled professionals and the high cost of devices is set to hamper market growth.The report segments the market by surgery, product, and geography. Based on surgery, the market is categorized into direct neuropathy, nerve grafting, stem cell therapy, and neuromodulation surgery. In 2016, the neuromodulation surgery segment generated the highest revenue in the global market, owing to the increase in patients suffering from neurological disorders. The segment is expected to continue is dominance throughout 2025.Based on the product, the report bifurcates the market into biomaterials and neuromodulation surgery devices. The neuromodulation surgery devices segment contributed the highest share in 2016, owing to the wide range of product offering for nerve repair. However, the nerve conduits sub-segment in biomaterials segment is projected to grow at a CAGR of 11.7% during the forecast period. Regionally, North America accounted for over two-fifths of the global market revenue in 2016, owing to growth in the number of patients suffering from neurological disorders.For Purchase Inquiry: https://www.alliedmarketresearch.com/purchase-enquiry/299?utm_source=Hitechnews&utm_medium=NiranjanThe report also profiles key players involved in the global nerve repair and regeneration market, such asAxoGen Inc. (U.S.),Nerve Repair and Regeneration MarketBaxter International (U.S.),Boston Scientific Incorporation (U.S.),Cyberonics Inc. (U.S.),Integra Lifesciences Corporation (U.S.),Medtronic Plc. (U.S.),Orthomed S.A.S. (France),Polyganics B.V. (Netherlands),Jude Medical (U.S.),Stryker Corporation (U.S.).They have adopted various strategies such as mergers & acquisitions, collaborations, partnerships, and others to gain a strong position in the industry.
Tags: Crystal Cruises, Israel, Jordan, Oman Travelweek Group << Previous PostNext Post >> Crystal Cruises heads back to Holy Land for the first time in 5 years Posted by LOS ANGELES — Crystal Cruises Chairman, President and CEO Edie Rodriguez will join passengers on the luxury cruise line’s first trip back to the Holy Land since 2012, as part of the 2017 ‘President’s Cruise’ aboard Crystal Symphony.The sailing departs Nov. 4 from Rome and features the Arabian Peninsula, with calls to Limassol, Cyprus; Haifa and Ashdod, Israel; a transit of the Suez Canal; Aqaba, Jordan; and Salalah and Muscat, Oman. Rodriguez and her husband Tom will join guests for festive receptions and parties on the 18-day voyage, as well as specially planned experiences ashore.“It is always a privilege to sail with members of the Crystal family and something to which I look forward each year,” says Rodriguez. “I am especially eager to experience this particular itinerary with our guests, and have the opportunity to explore Jordan.”Highlights include: the Rose City of Petra, where a special President’s shore excursion will take place; an overnight stay in Muscat in time for the Sultan’s extravagant birthday celebrations; adventurous archaeological expeditions; rock climbing; Indian Ocean scuba dives in Salalah; ‘Sky Tea’ at the opulent Burj Al Arab; and sunset at the Burj Khalifa in Dubai.More news: Venice to ban cruise ships from city centre starting next monthAll-inclusive cruise-only fares for the ‘Holy Land & Suez Canal’ voyage start at US$4,750 per person. Tuesday, December 13, 2016 Share
New Year’s resolution: don’t spend another year in a kitchen you don’t like More Valley freeways to be closed this weekend for improvements Natural spring cleaning tips and tricks for your home Think Tank analyzes the second round of Democratic debates Arizona families, Arizona farms: working to produce high-quality milk Like other Egyptians, they are now savoring the prospect of having their voice heard as the country begins voting on Wednesday for a new president, the first since the ouster last year of longtime leader Hosni Mubarak.The overwhelming concern for many of them is to stop any Islamist candidate from winning. Many of Egypt’s Christian minority _ about 20 percent of the population of 85 million _ are worried that if the fundamentalist Muslim Brotherhood candidate wins and moved to implement Islamic law, they will suffer greater discrimination.As a result, many are turning to the most anti-Islamist candidate on the slate of 13 hopefuls _ Ahmed Shafiq, a former air force commander who was Mubarak’s last prime minister.Anwar Rizk, a garbage collector in the neighborhood, says he’s backing Shafiq because “I fear the Muslim Brotherhood and the Salafis,” referring to a movement of ultraconservative Islamists. “We have Muslims living here as our brothers in very good conditions, but I fear the Muslim Brotherhood because they are only after their own good.”His fellow resident, Iskandar Shafiq _ no relation to the candidate _ agrees and is also impressed by the candidate’s strongman image. Comments Share Top Stories Associated PressCAIRO (AP) – Election fever has even come to Cairo’s Garbage City, the sprawling neighborhood built on _ and living from _ the waste of the Egyptian capital.The tens of thousands of impoverished residents of the district are almost all Christians. For generations, they have collected the garbage from the city of nearly 20 million; they sort it then recycle and sell what they can. Their homes are built in and around piles of the refuse, where their livestock graze. “Honestly we are going to elect Ahmed Shafiq because he is the one that can provide safety and security,” he said. “We feel this man is a politician like no other and frankly we have always known this man as a politician.”Along with Shafiq, the other front-runners in the contest are former foreign minister Amr Moussa; the Brotherhood’s Mohammed Morsi; and a moderate Islamist, Abdel-Moneim Abolfotoh, who has gained support from some liberals for his more open views. A leftist, Hamdeen Sabahi, has also gained ground among those who want neither an Islamist nor a former regime figure. Though few Christians are likely to vote for the Brotherhood’s Morsi, the community’s vote could be divided among the others.(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.) New high school in Mesa lets students pick career paths Meghan McCain to release audiobook on conservatism, family Sponsored Stories